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Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactive oxygen species (ROS) generation. DILIsym, a quan...

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Detalles Bibliográficos
Autores principales:	Woodhead, Jeffrey L., Paech, Franziska, Maurer, Martina, Engelhardt, Marc, Schmitt‐Hoffmann, Anne H., Spickermann, Jochen, Messner, Simon, Wind, Mathias, Witschi, Anne‐Therese, Krähenbühl, Stephan, Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132362/ https://www.ncbi.nlm.nih.gov/pubmed/29877622 http://dx.doi.org/10.1111/cts.12560

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