Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits us...

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Autores principales: Coussens, Nathan P., Sittampalam, G. Sitta, Guha, Rajarshi, Brimacombe, Kyle, Grossman, Abigail, Chung, Thomas D. Y., Weidner, Jeffrey R., Riss, Terry, Trask, O. Joseph, Auld, Douglas, Dahlin, Jayme L., Devanaryan, Viswanath, Foley, Timothy L., McGee, James, Kahl, Steven D., Kales, Stephen C., Arkin, Michelle, Baell, Jonathan, Bejcek, Bruce, Gal‐Edd, Neely, Glicksman, Marcie, Haas, Joseph V., Iversen, Philip W., Hoeppner, Marilu, Lathrop, Stacy, Sayers, Eric, Liu, Hanguan, Trawick, Bart, McVey, Julie, Lemmon, Vance P., Li, Zhuyin, McManus, Owen, Minor, Lisa, Napper, Andrew, Wildey, Mary Jo, Pacifici, Robert, Chin, William W., Xia, Menghang, Xu, Xin, Lal‐Nag, Madhu, Hall, Matthew D., Michael, Sam, Inglese, James, Simeonov, Anton, Austin, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132369/
https://www.ncbi.nlm.nih.gov/pubmed/29877628
http://dx.doi.org/10.1111/cts.12570
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author Coussens, Nathan P.
Sittampalam, G. Sitta
Guha, Rajarshi
Brimacombe, Kyle
Grossman, Abigail
Chung, Thomas D. Y.
Weidner, Jeffrey R.
Riss, Terry
Trask, O. Joseph
Auld, Douglas
Dahlin, Jayme L.
Devanaryan, Viswanath
Foley, Timothy L.
McGee, James
Kahl, Steven D.
Kales, Stephen C.
Arkin, Michelle
Baell, Jonathan
Bejcek, Bruce
Gal‐Edd, Neely
Glicksman, Marcie
Haas, Joseph V.
Iversen, Philip W.
Hoeppner, Marilu
Lathrop, Stacy
Sayers, Eric
Liu, Hanguan
Trawick, Bart
McVey, Julie
Lemmon, Vance P.
Li, Zhuyin
McManus, Owen
Minor, Lisa
Napper, Andrew
Wildey, Mary Jo
Pacifici, Robert
Chin, William W.
Xia, Menghang
Xu, Xin
Lal‐Nag, Madhu
Hall, Matthew D.
Michael, Sam
Inglese, James
Simeonov, Anton
Austin, Christopher P.
author_facet Coussens, Nathan P.
Sittampalam, G. Sitta
Guha, Rajarshi
Brimacombe, Kyle
Grossman, Abigail
Chung, Thomas D. Y.
Weidner, Jeffrey R.
Riss, Terry
Trask, O. Joseph
Auld, Douglas
Dahlin, Jayme L.
Devanaryan, Viswanath
Foley, Timothy L.
McGee, James
Kahl, Steven D.
Kales, Stephen C.
Arkin, Michelle
Baell, Jonathan
Bejcek, Bruce
Gal‐Edd, Neely
Glicksman, Marcie
Haas, Joseph V.
Iversen, Philip W.
Hoeppner, Marilu
Lathrop, Stacy
Sayers, Eric
Liu, Hanguan
Trawick, Bart
McVey, Julie
Lemmon, Vance P.
Li, Zhuyin
McManus, Owen
Minor, Lisa
Napper, Andrew
Wildey, Mary Jo
Pacifici, Robert
Chin, William W.
Xia, Menghang
Xu, Xin
Lal‐Nag, Madhu
Hall, Matthew D.
Michael, Sam
Inglese, James
Simeonov, Anton
Austin, Christopher P.
author_sort Coussens, Nathan P.
collection PubMed
description The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
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spelling pubmed-61323692018-09-13 Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery Coussens, Nathan P. Sittampalam, G. Sitta Guha, Rajarshi Brimacombe, Kyle Grossman, Abigail Chung, Thomas D. Y. Weidner, Jeffrey R. Riss, Terry Trask, O. Joseph Auld, Douglas Dahlin, Jayme L. Devanaryan, Viswanath Foley, Timothy L. McGee, James Kahl, Steven D. Kales, Stephen C. Arkin, Michelle Baell, Jonathan Bejcek, Bruce Gal‐Edd, Neely Glicksman, Marcie Haas, Joseph V. Iversen, Philip W. Hoeppner, Marilu Lathrop, Stacy Sayers, Eric Liu, Hanguan Trawick, Bart McVey, Julie Lemmon, Vance P. Li, Zhuyin McManus, Owen Minor, Lisa Napper, Andrew Wildey, Mary Jo Pacifici, Robert Chin, William W. Xia, Menghang Xu, Xin Lal‐Nag, Madhu Hall, Matthew D. Michael, Sam Inglese, James Simeonov, Anton Austin, Christopher P. Clin Transl Sci Tutorial The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists. John Wiley and Sons Inc. 2018-07-24 2018-09 /pmc/articles/PMC6132369/ /pubmed/29877628 http://dx.doi.org/10.1111/cts.12570 Text en © 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Tutorial
Coussens, Nathan P.
Sittampalam, G. Sitta
Guha, Rajarshi
Brimacombe, Kyle
Grossman, Abigail
Chung, Thomas D. Y.
Weidner, Jeffrey R.
Riss, Terry
Trask, O. Joseph
Auld, Douglas
Dahlin, Jayme L.
Devanaryan, Viswanath
Foley, Timothy L.
McGee, James
Kahl, Steven D.
Kales, Stephen C.
Arkin, Michelle
Baell, Jonathan
Bejcek, Bruce
Gal‐Edd, Neely
Glicksman, Marcie
Haas, Joseph V.
Iversen, Philip W.
Hoeppner, Marilu
Lathrop, Stacy
Sayers, Eric
Liu, Hanguan
Trawick, Bart
McVey, Julie
Lemmon, Vance P.
Li, Zhuyin
McManus, Owen
Minor, Lisa
Napper, Andrew
Wildey, Mary Jo
Pacifici, Robert
Chin, William W.
Xia, Menghang
Xu, Xin
Lal‐Nag, Madhu
Hall, Matthew D.
Michael, Sam
Inglese, James
Simeonov, Anton
Austin, Christopher P.
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
title Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
title_full Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
title_fullStr Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
title_full_unstemmed Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
title_short Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
title_sort assay guidance manual: quantitative biology and pharmacology in preclinical drug discovery
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132369/
https://www.ncbi.nlm.nih.gov/pubmed/29877628
http://dx.doi.org/10.1111/cts.12570
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