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Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrP(C)

Prion diseases are infectious and fatal neurodegenerative diseases affecting humans and animals. Transmission is possible within and between species with zoonotic potential. Currently, no prophylaxis or treatment exists. Prions are composed of the misfolded isoform PrP(Sc) of the cellular prion prot...

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Detalles Bibliográficos
Autores principales:	Corda, Erica, Du, Xiaotang, Shim, Su Yeon, Klein, Antonia N., Siltberg-Liberles, Jessica, Gilch, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132731/ https://www.ncbi.nlm.nih.gov/pubmed/29460268 http://dx.doi.org/10.1007/s12035-018-0944-9

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