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NMR (1)H,(13)C, (15)N backbone and (13)C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP
K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by guanine nucleotide exchange factors and GTPase activating proteins, respectively. Activated K-Ras re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132845/ https://www.ncbi.nlm.nih.gov/pubmed/29721757 http://dx.doi.org/10.1007/s12104-018-9821-8 |