Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress

Fibrosis is a hallmark of maladaptive cardiac remodelling. Here we report that genome-wide quantitative trait locus (QTL) analyses in recombinant inbred mouse lines of C57BL/6 J and DBA2/J strains identified Raf Kinase Inhibitor Protein (RKIP) as genetic marker of fibrosis progression. C57BL/6 N-RKI...

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Detalles Bibliográficos
Autores principales: Kazakov, Andrey, Hall, Rabea A., Werner, Christian, Meier, Timo, Trouvain, André, Rodionycheva, Svetlana, Nickel, Alexander, Lammert, Frank, Maack, Christoph, Böhm, Michael, Laufs, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133069/
https://www.ncbi.nlm.nih.gov/pubmed/30191336
http://dx.doi.org/10.1007/s00395-018-0700-3

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