In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats

BACKGROUND AND OBJECTIVES: Treosulfan is a prodrug applied in the treatment of ovarian cancer and conditioning prior to stem cell transplantation. So far, the bioanalysis of treosulfan in either whole blood or red blood cells (RBC) has not been carried out. In this work, the RBC/plasma partition coe...

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Detalles Bibliográficos
Autores principales: Romański, Michał, Zacharzewska, Anna, Teżyk, Artur, Główka, Franciszek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133075/
https://www.ncbi.nlm.nih.gov/pubmed/29542019
http://dx.doi.org/10.1007/s13318-018-0469-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133075/
https://www.ncbi.nlm.nih.gov/pubmed/29542019
http://dx.doi.org/10.1007/s13318-018-0469-7

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