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Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration

BACKGROUND AND OBJECTIVE: P-glycoprotein (P-gp), a transmembrane transporter expressed at the blood–brain barrier, restricts the distribution of diverse central nervous system-targeted drugs from blood into brain, reducing their therapeutic efficacy. The third-generation P-gp inhibitor tariquidar (X...

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Detalles Bibliográficos
Autores principales:	Matzneller, Peter, Kussmann, Manuel, Eberl, Sabine, Maier-Salamon, Alexandra, Jäger, Walter, Bauer, Martin, Langer, Oliver, Zeitlinger, Markus, Poeppl, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133083/ https://www.ncbi.nlm.nih.gov/pubmed/29616423 http://dx.doi.org/10.1007/s13318-018-0474-x

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