STIM1 deficiency is linked to Alzheimer’s disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca(2+) entry

ABSTRACT: STIM1 is an endoplasmic reticulum protein with a role in Ca(2+) mobilization and signaling. As a sensor of intraluminal Ca(2+) levels, STIM1 modulates plasma membrane Ca(2+) channels to regulate Ca(2+) entry. In neuroblastoma SH-SY5Y cells and in familial Alzheimer’s disease patient skin f...

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Detalles Bibliográficos
Autores principales: Pascual-Caro, Carlos, Berrocal, Maria, Lopez-Guerrero, Aida M., Alvarez-Barrientos, Alberto, Pozo-Guisado, Eulalia, Gutierrez-Merino, Carlos, Mata, Ana M., Martin-Romero, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133163/
https://www.ncbi.nlm.nih.gov/pubmed/30088035
http://dx.doi.org/10.1007/s00109-018-1677-y

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