Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells

OBJECTIVE: IL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and generally acts as an activating signal. H...

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Detalles Bibliográficos
Autores principales: Ono, Hiroaki, Ohta, Ryo, Kawasaki, Yuri, Niwa, Akira, Takada, Hidetoshi, Nakahata, Tatsutoshi, Ohga, Shouichi, Saito, Megumu K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133165/
https://www.ncbi.nlm.nih.gov/pubmed/30136196
http://dx.doi.org/10.1007/s00011-018-1178-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133165/
https://www.ncbi.nlm.nih.gov/pubmed/30136196
http://dx.doi.org/10.1007/s00011-018-1178-z

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