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Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
OBJECTIVE: IL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and generally acts as an activating signal. H...
Autores principales: | Ono, Hiroaki, Ohta, Ryo, Kawasaki, Yuri, Niwa, Akira, Takada, Hidetoshi, Nakahata, Tatsutoshi, Ohga, Shouichi, Saito, Megumu K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133165/ https://www.ncbi.nlm.nih.gov/pubmed/30136196 http://dx.doi.org/10.1007/s00011-018-1178-z |
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