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Safety, Tolerability and Pharmacokinetics of MEDI8897, an Extended Half-life Single-dose Respiratory Syncytial Virus Prefusion F-targeting Monoclonal Antibody Administered as a Single Dose to Healthy Preterm Infants

BACKGROUND: MEDI8897 is a recombinant human monoclonal antibody being developed for prophylaxis of serious respiratory syncytial virus (RSV) disease in all infants. METHODS: In this phase 1b/2a dose-escalation study, healthy preterm infants with a gestational age of 32–35 weeks were randomized to re...

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Detalles Bibliográficos
Autores principales:	Domachowske, Joseph B., Khan, Anis A., Esser, Mark T., Jensen, Kathryn, Takas, Therese, Villafana, Tonya, Dubovsky, Filip, Griffin, M. Pamela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Williams & Wilkins 2018
Materias:	Antimicrobial Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133204/ https://www.ncbi.nlm.nih.gov/pubmed/29373476 http://dx.doi.org/10.1097/INF.0000000000001916

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