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Proteomics and melanoma: a current perspective

Proteomics is the study of the protein complement of the genome, and this powerful technique complements genomic studies. Proteomic experiments result in the generation of large volumes of data requiring complicated analysis algorithms and subsequent confirmatory studies. Until recently, technologic...

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Detalles Bibliográficos
Autores principales: Shields, Bradley D, Tackett, Alan J, Shalin, Sara C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133306/
https://www.ncbi.nlm.nih.gov/pubmed/30214824
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author Shields, Bradley D
Tackett, Alan J
Shalin, Sara C
author_facet Shields, Bradley D
Tackett, Alan J
Shalin, Sara C
author_sort Shields, Bradley D
collection PubMed
description Proteomics is the study of the protein complement of the genome, and this powerful technique complements genomic studies. Proteomic experiments result in the generation of large volumes of data requiring complicated analysis algorithms and subsequent confirmatory studies. Until recently, technological limitations of experimental protocols precluded the use of formalin-fixed tissues for these types of studies. Recent advances have allowed the use of valuable archived patient tissue samples in proteomic research, resulting in an opportunity to perform cutting edge translational research. The field of melanoma research stands to benefit greatly from collaboration between dermatopathologists and proteomic scientists. This article seeks to: 1) describe proteomics for dermatologists and pathologists, including the tools used in proteomic research, and 2) convey a historical account of proteomic studies within the field of melanoma followed by a discussion on how recent advances are informing current studies.
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spelling pubmed-61333062018-09-11 Proteomics and melanoma: a current perspective Shields, Bradley D Tackett, Alan J Shalin, Sara C Glob Dermatol Article Proteomics is the study of the protein complement of the genome, and this powerful technique complements genomic studies. Proteomic experiments result in the generation of large volumes of data requiring complicated analysis algorithms and subsequent confirmatory studies. Until recently, technological limitations of experimental protocols precluded the use of formalin-fixed tissues for these types of studies. Recent advances have allowed the use of valuable archived patient tissue samples in proteomic research, resulting in an opportunity to perform cutting edge translational research. The field of melanoma research stands to benefit greatly from collaboration between dermatopathologists and proteomic scientists. This article seeks to: 1) describe proteomics for dermatologists and pathologists, including the tools used in proteomic research, and 2) convey a historical account of proteomic studies within the field of melanoma followed by a discussion on how recent advances are informing current studies. 2016-06-20 2016-08 /pmc/articles/PMC6133306/ /pubmed/30214824 Text en http://creativecommons.org/licenses/by/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Shields, Bradley D
Tackett, Alan J
Shalin, Sara C
Proteomics and melanoma: a current perspective
title Proteomics and melanoma: a current perspective
title_full Proteomics and melanoma: a current perspective
title_fullStr Proteomics and melanoma: a current perspective
title_full_unstemmed Proteomics and melanoma: a current perspective
title_short Proteomics and melanoma: a current perspective
title_sort proteomics and melanoma: a current perspective
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133306/
https://www.ncbi.nlm.nih.gov/pubmed/30214824
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