The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen

The vacuolar-type H(+)-ATPase (v-ATPase) is the major proton pump that acidifies intracellular compartments of eukaryotic cells. Since the inhibition of v-ATPase resulted in anti-tumor and anti-metastatic effects in different tumor models, this enzyme has emerged as promising strategy against cancer...

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Detalles Bibliográficos
Autores principales: Luong, Betty, Schwenk, Rebecca, Bräutigam, Jacqueline, Müller, Rolf, Menche, Dirk, Bischoff, Iris, Fürst, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133348/
https://www.ncbi.nlm.nih.gov/pubmed/30204757
http://dx.doi.org/10.1371/journal.pone.0203053

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