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Intrinsically regulated learning is modulated by synaptic dopamine signaling

We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hi...

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Autores principales: Ripollés, Pablo, Ferreri, Laura, Mas-Herrero, Ernest, Alicart, Helena, Gómez-Andrés, Alba, Marco-Pallares, Josep, Antonijoan, Rosa Maria, Noesselt, Toemme, Valle, Marta, Riba, Jordi, Rodriguez-Fornells, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133552/
https://www.ncbi.nlm.nih.gov/pubmed/30160651
http://dx.doi.org/10.7554/eLife.38113
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author Ripollés, Pablo
Ferreri, Laura
Mas-Herrero, Ernest
Alicart, Helena
Gómez-Andrés, Alba
Marco-Pallares, Josep
Antonijoan, Rosa Maria
Noesselt, Toemme
Valle, Marta
Riba, Jordi
Rodriguez-Fornells, Antoni
author_facet Ripollés, Pablo
Ferreri, Laura
Mas-Herrero, Ernest
Alicart, Helena
Gómez-Andrés, Alba
Marco-Pallares, Josep
Antonijoan, Rosa Maria
Noesselt, Toemme
Valle, Marta
Riba, Jordi
Rodriguez-Fornells, Antoni
author_sort Ripollés, Pablo
collection PubMed
description We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.
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spelling pubmed-61335522018-09-12 Intrinsically regulated learning is modulated by synaptic dopamine signaling Ripollés, Pablo Ferreri, Laura Mas-Herrero, Ernest Alicart, Helena Gómez-Andrés, Alba Marco-Pallares, Josep Antonijoan, Rosa Maria Noesselt, Toemme Valle, Marta Riba, Jordi Rodriguez-Fornells, Antoni eLife Neuroscience We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success. eLife Sciences Publications, Ltd 2018-08-30 /pmc/articles/PMC6133552/ /pubmed/30160651 http://dx.doi.org/10.7554/eLife.38113 Text en © 2018, Ripollés et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Ripollés, Pablo
Ferreri, Laura
Mas-Herrero, Ernest
Alicart, Helena
Gómez-Andrés, Alba
Marco-Pallares, Josep
Antonijoan, Rosa Maria
Noesselt, Toemme
Valle, Marta
Riba, Jordi
Rodriguez-Fornells, Antoni
Intrinsically regulated learning is modulated by synaptic dopamine signaling
title Intrinsically regulated learning is modulated by synaptic dopamine signaling
title_full Intrinsically regulated learning is modulated by synaptic dopamine signaling
title_fullStr Intrinsically regulated learning is modulated by synaptic dopamine signaling
title_full_unstemmed Intrinsically regulated learning is modulated by synaptic dopamine signaling
title_short Intrinsically regulated learning is modulated by synaptic dopamine signaling
title_sort intrinsically regulated learning is modulated by synaptic dopamine signaling
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133552/
https://www.ncbi.nlm.nih.gov/pubmed/30160651
http://dx.doi.org/10.7554/eLife.38113
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