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Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
BACKGROUND: The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. METHODS: Twenty-two eligible studies were identified using the PubMed and Goo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133557/ https://www.ncbi.nlm.nih.gov/pubmed/30095632 http://dx.doi.org/10.1097/MD.0000000000011769 |
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author | Lee, Jung Soo Won, Hye Sung Sun, Der Sheng Hong, Ji Hyung Ko, Yoon Ho |
author_facet | Lee, Jung Soo Won, Hye Sung Sun, Der Sheng Hong, Ji Hyung Ko, Yoon Ho |
author_sort | Lee, Jung Soo |
collection | PubMed |
description | BACKGROUND: The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. METHODS: Twenty-two eligible studies were identified using the PubMed and Google Scholar databases. The combined sample size of the 22 studies was 2941, and the median sample size of the individual studies was 122 patients (52–220). The main clinical outcomes examined were overall cancer survival (OCS) and overall cancer relapse-free survival (OCRFS). RESULTS: Tumor tissue CD3(+) TILs, indicative of pan-T-cell expression, had a positive effect on survival with a hazard ratio (HR) of 0.64 (95% confidence interval [CI] 0.52–0.78) for OCS, as did the non-FOXP3(+) T-cell subgroup with an HR of 0.66 (95% CI 0.57–0.75), particularly in CD8(+) lymphocytes (HR = 0.63, 95% CI 0.48–0.83). On the contrary, high FOXP3(+) T-cell expression was correlated with reduced OCS, with an HR of 1.75 (95% CI 1.26–2.42). Analysis of the seven studies evaluating OCRFS revealed improved OCRFS with infiltration of non-FOXP3(+) TILs with an HR of 0.59 (95% CI 0.42–0.81) but not FOXP3(+) T lymphocytes with an HR of 1.82 (95% CI 1.30–2.53). CONCLUSION: The results from this meta-analysis suggest that high expression of TILs, mainly by CD8 lymphocytes, may be a potential prognostic biomarker in patients with gastric cancer. |
format | Online Article Text |
id | pubmed-6133557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-61335572018-09-19 Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis Lee, Jung Soo Won, Hye Sung Sun, Der Sheng Hong, Ji Hyung Ko, Yoon Ho Medicine (Baltimore) Research Article BACKGROUND: The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. METHODS: Twenty-two eligible studies were identified using the PubMed and Google Scholar databases. The combined sample size of the 22 studies was 2941, and the median sample size of the individual studies was 122 patients (52–220). The main clinical outcomes examined were overall cancer survival (OCS) and overall cancer relapse-free survival (OCRFS). RESULTS: Tumor tissue CD3(+) TILs, indicative of pan-T-cell expression, had a positive effect on survival with a hazard ratio (HR) of 0.64 (95% confidence interval [CI] 0.52–0.78) for OCS, as did the non-FOXP3(+) T-cell subgroup with an HR of 0.66 (95% CI 0.57–0.75), particularly in CD8(+) lymphocytes (HR = 0.63, 95% CI 0.48–0.83). On the contrary, high FOXP3(+) T-cell expression was correlated with reduced OCS, with an HR of 1.75 (95% CI 1.26–2.42). Analysis of the seven studies evaluating OCRFS revealed improved OCRFS with infiltration of non-FOXP3(+) TILs with an HR of 0.59 (95% CI 0.42–0.81) but not FOXP3(+) T lymphocytes with an HR of 1.82 (95% CI 1.30–2.53). CONCLUSION: The results from this meta-analysis suggest that high expression of TILs, mainly by CD8 lymphocytes, may be a potential prognostic biomarker in patients with gastric cancer. Wolters Kluwer Health 2018-08-10 /pmc/articles/PMC6133557/ /pubmed/30095632 http://dx.doi.org/10.1097/MD.0000000000011769 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Lee, Jung Soo Won, Hye Sung Sun, Der Sheng Hong, Ji Hyung Ko, Yoon Ho Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis |
title | Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis |
title_full | Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis |
title_fullStr | Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis |
title_full_unstemmed | Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis |
title_short | Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis |
title_sort | prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133557/ https://www.ncbi.nlm.nih.gov/pubmed/30095632 http://dx.doi.org/10.1097/MD.0000000000011769 |
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