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Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis

BACKGROUND: The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. METHODS: Twenty-two eligible studies were identified using the PubMed and Goo...

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Autores principales: Lee, Jung Soo, Won, Hye Sung, Sun, Der Sheng, Hong, Ji Hyung, Ko, Yoon Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133557/
https://www.ncbi.nlm.nih.gov/pubmed/30095632
http://dx.doi.org/10.1097/MD.0000000000011769
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author Lee, Jung Soo
Won, Hye Sung
Sun, Der Sheng
Hong, Ji Hyung
Ko, Yoon Ho
author_facet Lee, Jung Soo
Won, Hye Sung
Sun, Der Sheng
Hong, Ji Hyung
Ko, Yoon Ho
author_sort Lee, Jung Soo
collection PubMed
description BACKGROUND: The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. METHODS: Twenty-two eligible studies were identified using the PubMed and Google Scholar databases. The combined sample size of the 22 studies was 2941, and the median sample size of the individual studies was 122 patients (52–220). The main clinical outcomes examined were overall cancer survival (OCS) and overall cancer relapse-free survival (OCRFS). RESULTS: Tumor tissue CD3(+) TILs, indicative of pan-T-cell expression, had a positive effect on survival with a hazard ratio (HR) of 0.64 (95% confidence interval [CI] 0.52–0.78) for OCS, as did the non-FOXP3(+) T-cell subgroup with an HR of 0.66 (95% CI 0.57–0.75), particularly in CD8(+) lymphocytes (HR = 0.63, 95% CI 0.48–0.83). On the contrary, high FOXP3(+) T-cell expression was correlated with reduced OCS, with an HR of 1.75 (95% CI 1.26–2.42). Analysis of the seven studies evaluating OCRFS revealed improved OCRFS with infiltration of non-FOXP3(+) TILs with an HR of 0.59 (95% CI 0.42–0.81) but not FOXP3(+) T lymphocytes with an HR of 1.82 (95% CI 1.30–2.53). CONCLUSION: The results from this meta-analysis suggest that high expression of TILs, mainly by CD8 lymphocytes, may be a potential prognostic biomarker in patients with gastric cancer.
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spelling pubmed-61335572018-09-19 Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis Lee, Jung Soo Won, Hye Sung Sun, Der Sheng Hong, Ji Hyung Ko, Yoon Ho Medicine (Baltimore) Research Article BACKGROUND: The potential prognostic value of tumor-infiltrating lymphocytes (TILs) in gastric cancer remains controversial. This meta-analysis examines the association between TILs and survival outcomes in gastric cancer. METHODS: Twenty-two eligible studies were identified using the PubMed and Google Scholar databases. The combined sample size of the 22 studies was 2941, and the median sample size of the individual studies was 122 patients (52–220). The main clinical outcomes examined were overall cancer survival (OCS) and overall cancer relapse-free survival (OCRFS). RESULTS: Tumor tissue CD3(+) TILs, indicative of pan-T-cell expression, had a positive effect on survival with a hazard ratio (HR) of 0.64 (95% confidence interval [CI] 0.52–0.78) for OCS, as did the non-FOXP3(+) T-cell subgroup with an HR of 0.66 (95% CI 0.57–0.75), particularly in CD8(+) lymphocytes (HR = 0.63, 95% CI 0.48–0.83). On the contrary, high FOXP3(+) T-cell expression was correlated with reduced OCS, with an HR of 1.75 (95% CI 1.26–2.42). Analysis of the seven studies evaluating OCRFS revealed improved OCRFS with infiltration of non-FOXP3(+) TILs with an HR of 0.59 (95% CI 0.42–0.81) but not FOXP3(+) T lymphocytes with an HR of 1.82 (95% CI 1.30–2.53). CONCLUSION: The results from this meta-analysis suggest that high expression of TILs, mainly by CD8 lymphocytes, may be a potential prognostic biomarker in patients with gastric cancer. Wolters Kluwer Health 2018-08-10 /pmc/articles/PMC6133557/ /pubmed/30095632 http://dx.doi.org/10.1097/MD.0000000000011769 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Lee, Jung Soo
Won, Hye Sung
Sun, Der Sheng
Hong, Ji Hyung
Ko, Yoon Ho
Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
title Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
title_full Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
title_fullStr Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
title_full_unstemmed Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
title_short Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis
title_sort prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133557/
https://www.ncbi.nlm.nih.gov/pubmed/30095632
http://dx.doi.org/10.1097/MD.0000000000011769
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