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Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea

In this study, we assess the possibility of using procalcitonin levels to differentiate between inflammatory diarrhea and non-inflammatory diarrhea in acute infectious diarrhea. We reviewed the records of 1176 patients who had symptoms of diarrhea, fever (≥37.8 °C), and abdominal pain between March...

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Autores principales: Shin, Hae Jin, Kang, Sun Hyung, Moon, Hee Seok, Sung, Jae Kyu, Jeong, Hyun Yong, Kim, Ju Seok, Joo, Jong Seok, Lee, Eaum Seok, Kim, Seok Hyun, Lee, Byung Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133584/
https://www.ncbi.nlm.nih.gov/pubmed/30095641
http://dx.doi.org/10.1097/MD.0000000000011795
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author Shin, Hae Jin
Kang, Sun Hyung
Moon, Hee Seok
Sung, Jae Kyu
Jeong, Hyun Yong
Kim, Ju Seok
Joo, Jong Seok
Lee, Eaum Seok
Kim, Seok Hyun
Lee, Byung Seok
author_facet Shin, Hae Jin
Kang, Sun Hyung
Moon, Hee Seok
Sung, Jae Kyu
Jeong, Hyun Yong
Kim, Ju Seok
Joo, Jong Seok
Lee, Eaum Seok
Kim, Seok Hyun
Lee, Byung Seok
author_sort Shin, Hae Jin
collection PubMed
description In this study, we assess the possibility of using procalcitonin levels to differentiate between inflammatory diarrhea and non-inflammatory diarrhea in acute infectious diarrhea. We reviewed the records of 1176 patients who had symptoms of diarrhea, fever (≥37.8 °C), and abdominal pain between March 2011 and May 2015. After applying exclusion criteria, a sample of 514 patients was considered for study. The patient sample was divided into Group A and Group B for inflammatory diarrhea and non-inflammatory diarrhea, respectively. The assessment involved comparing the laboratory characteristics with the clinical characteristics of the groups. The characteristics of Group A, such as white blood cell (WBC), C-reactive protein (CRP), absolute neutrophil count (ANC), and procalcitonin levels, were relatively higher than those of Group B (P < .001 for Group A). A receiver operator characteristic (ROC) analysis revealed that the highest area-under-the-curve (AUC) value of procalcitonin (0.797; 95% confidence interval [CI] [0.760, 0.831]; P < .001), could be used to differentiate between the 2 groups. Procalcitonin exhibited a sensitivity and a specificity of 87.03% and 68.75%, respectively, at a 0.08 ng/mL cut-off level. Procalcitonin was a good candidate biomarker of inflammatory diarrhea than other inflammatory markers.
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spelling pubmed-61335842018-09-19 Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea Shin, Hae Jin Kang, Sun Hyung Moon, Hee Seok Sung, Jae Kyu Jeong, Hyun Yong Kim, Ju Seok Joo, Jong Seok Lee, Eaum Seok Kim, Seok Hyun Lee, Byung Seok Medicine (Baltimore) Research Article In this study, we assess the possibility of using procalcitonin levels to differentiate between inflammatory diarrhea and non-inflammatory diarrhea in acute infectious diarrhea. We reviewed the records of 1176 patients who had symptoms of diarrhea, fever (≥37.8 °C), and abdominal pain between March 2011 and May 2015. After applying exclusion criteria, a sample of 514 patients was considered for study. The patient sample was divided into Group A and Group B for inflammatory diarrhea and non-inflammatory diarrhea, respectively. The assessment involved comparing the laboratory characteristics with the clinical characteristics of the groups. The characteristics of Group A, such as white blood cell (WBC), C-reactive protein (CRP), absolute neutrophil count (ANC), and procalcitonin levels, were relatively higher than those of Group B (P < .001 for Group A). A receiver operator characteristic (ROC) analysis revealed that the highest area-under-the-curve (AUC) value of procalcitonin (0.797; 95% confidence interval [CI] [0.760, 0.831]; P < .001), could be used to differentiate between the 2 groups. Procalcitonin exhibited a sensitivity and a specificity of 87.03% and 68.75%, respectively, at a 0.08 ng/mL cut-off level. Procalcitonin was a good candidate biomarker of inflammatory diarrhea than other inflammatory markers. Wolters Kluwer Health 2018-08-10 /pmc/articles/PMC6133584/ /pubmed/30095641 http://dx.doi.org/10.1097/MD.0000000000011795 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Shin, Hae Jin
Kang, Sun Hyung
Moon, Hee Seok
Sung, Jae Kyu
Jeong, Hyun Yong
Kim, Ju Seok
Joo, Jong Seok
Lee, Eaum Seok
Kim, Seok Hyun
Lee, Byung Seok
Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
title Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
title_full Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
title_fullStr Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
title_full_unstemmed Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
title_short Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
title_sort serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133584/
https://www.ncbi.nlm.nih.gov/pubmed/30095641
http://dx.doi.org/10.1097/MD.0000000000011795
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