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Secondary basal cell carcinoma of scalp after radiotherapy: A case report
RATIONALE: Radiotherapy (RT) is widely used for both malignant and benign tumors in order to reduce the risk of recurrence, to promote tumor control, and to improve survival. However, there have been studies reported that RT is also a risk factor of secondary cancer. Very few cases of secondary mali...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133595/ https://www.ncbi.nlm.nih.gov/pubmed/30200117 http://dx.doi.org/10.1097/MD.0000000000012170 |
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author | Chen, Frank Yang, Sheau-Fang Chen, Chien-Hung Lieu, Ann-Shung Cheng, Shih-Tsung Huang, Ming-Yii Lee, Hsin-Hua |
author_facet | Chen, Frank Yang, Sheau-Fang Chen, Chien-Hung Lieu, Ann-Shung Cheng, Shih-Tsung Huang, Ming-Yii Lee, Hsin-Hua |
author_sort | Chen, Frank |
collection | PubMed |
description | RATIONALE: Radiotherapy (RT) is widely used for both malignant and benign tumors in order to reduce the risk of recurrence, to promote tumor control, and to improve survival. However, there have been studies reported that RT is also a risk factor of secondary cancer. Very few cases of secondary malignancy after RT to high grade brain cancer have been reported due to short survival of this disease, and most RT-induced malignancies presented with sarcomatous histology. Here we present a patient with basal cell carcinoma (BCC) 14 years after RT to his brain. PATIENT CONCERNS: A 28-year-old man without any underlying disease had suffered from left side weakness and clonic-tonic seizures for 12 days. DIAGNOSES: His brain images showed a tumor in the right frontal lobe. The pathologic report confirmed anaplastic astrocytoma (WHO Grade III). INTERVENTIONS: After craniotomy and tumor biopsy, RT was delivered. Fourteen years later, a gray-colored skin papule was noted in the previously irradiated area. The scalp biopsy revealed BCC. The scalp BCC was adequately resected. He then suffered from brain tumor recurrence and received further craniotomy for three times combined with chemotherapy with temozolomide. OUTCOMES: After treatment, follow-up brain images showed that the disease was under control. There was no neurological sequela. For scalp BCC, no skin tumor recurrence has been noted to date after the resection 14 years after initial RT. He has survived for more than 26 years since his initial diagnosis of anaplastic astrocytoma, and more than 12 years from the diagnosis of scalp BCC. LESSONS: Notwithstanding the risk of radiation-induced skin cancer, RT contributed to this patient's survival. The possible late adverse events should be informed to the patients. |
format | Online Article Text |
id | pubmed-6133595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-61335952018-09-19 Secondary basal cell carcinoma of scalp after radiotherapy: A case report Chen, Frank Yang, Sheau-Fang Chen, Chien-Hung Lieu, Ann-Shung Cheng, Shih-Tsung Huang, Ming-Yii Lee, Hsin-Hua Medicine (Baltimore) Research Article RATIONALE: Radiotherapy (RT) is widely used for both malignant and benign tumors in order to reduce the risk of recurrence, to promote tumor control, and to improve survival. However, there have been studies reported that RT is also a risk factor of secondary cancer. Very few cases of secondary malignancy after RT to high grade brain cancer have been reported due to short survival of this disease, and most RT-induced malignancies presented with sarcomatous histology. Here we present a patient with basal cell carcinoma (BCC) 14 years after RT to his brain. PATIENT CONCERNS: A 28-year-old man without any underlying disease had suffered from left side weakness and clonic-tonic seizures for 12 days. DIAGNOSES: His brain images showed a tumor in the right frontal lobe. The pathologic report confirmed anaplastic astrocytoma (WHO Grade III). INTERVENTIONS: After craniotomy and tumor biopsy, RT was delivered. Fourteen years later, a gray-colored skin papule was noted in the previously irradiated area. The scalp biopsy revealed BCC. The scalp BCC was adequately resected. He then suffered from brain tumor recurrence and received further craniotomy for three times combined with chemotherapy with temozolomide. OUTCOMES: After treatment, follow-up brain images showed that the disease was under control. There was no neurological sequela. For scalp BCC, no skin tumor recurrence has been noted to date after the resection 14 years after initial RT. He has survived for more than 26 years since his initial diagnosis of anaplastic astrocytoma, and more than 12 years from the diagnosis of scalp BCC. LESSONS: Notwithstanding the risk of radiation-induced skin cancer, RT contributed to this patient's survival. The possible late adverse events should be informed to the patients. Wolters Kluwer Health 2018-09-07 /pmc/articles/PMC6133595/ /pubmed/30200117 http://dx.doi.org/10.1097/MD.0000000000012170 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Chen, Frank Yang, Sheau-Fang Chen, Chien-Hung Lieu, Ann-Shung Cheng, Shih-Tsung Huang, Ming-Yii Lee, Hsin-Hua Secondary basal cell carcinoma of scalp after radiotherapy: A case report |
title | Secondary basal cell carcinoma of scalp after radiotherapy: A case report |
title_full | Secondary basal cell carcinoma of scalp after radiotherapy: A case report |
title_fullStr | Secondary basal cell carcinoma of scalp after radiotherapy: A case report |
title_full_unstemmed | Secondary basal cell carcinoma of scalp after radiotherapy: A case report |
title_short | Secondary basal cell carcinoma of scalp after radiotherapy: A case report |
title_sort | secondary basal cell carcinoma of scalp after radiotherapy: a case report |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133595/ https://www.ncbi.nlm.nih.gov/pubmed/30200117 http://dx.doi.org/10.1097/MD.0000000000012170 |
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