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Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion

The outcomes following anterior approach (AA) hepatectomy in huge hepatocellular carcinoma (HCC) patients with diaphragmatic invasion (DI) remain unclear. This study compared the outcomes of single huge right HCC patients with and without DI after AA hepatectomy. A total of 203 consecutive patients...

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Autores principales: Zheng, Jinli, Shen, Shu, Jiang, Li, Yan, Lunan, Yang, Jiayin, Li, Bo, Wen, Tianfu, Wang, WenTao, Xu, Mingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133608/
https://www.ncbi.nlm.nih.gov/pubmed/30200125
http://dx.doi.org/10.1097/MD.0000000000012194
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author Zheng, Jinli
Shen, Shu
Jiang, Li
Yan, Lunan
Yang, Jiayin
Li, Bo
Wen, Tianfu
Wang, WenTao
Xu, Mingqing
author_facet Zheng, Jinli
Shen, Shu
Jiang, Li
Yan, Lunan
Yang, Jiayin
Li, Bo
Wen, Tianfu
Wang, WenTao
Xu, Mingqing
author_sort Zheng, Jinli
collection PubMed
description The outcomes following anterior approach (AA) hepatectomy in huge hepatocellular carcinoma (HCC) patients with diaphragmatic invasion (DI) remain unclear. This study compared the outcomes of single huge right HCC patients with and without DI after AA hepatectomy. A total of 203 consecutive patients with single huge right lobe HCC who underwent AA major hepatectomy were included. They were divided into group PDI (n = 53) and group ADI (n = 150) according to the presence or the absence of DI. Their short- and long-term outcomes were compared, and a subgroup analysis was performed. There were no significant differences regarding postoperative complications and 90-day mortality between the 2 groups. The overall survival (OS) and recurrence-free survival (RFS) rates were similar between the 2 groups. The subgroup analysis also showed that patients with tumor resection en bloc with part of the diaphragm had similar OS and RFS rates as those who underwent diaphragmatic resection after hepatectomy. Tumor diameter ≥ 15 cm, serum AFP level ≥ 400 ng/mL, and tumor grade of G4 and microvascular invasion are independent predictors of poor prognosis. For the single huge right lobe HCC patients with DI, AA major hepatectomy combined with diaphragmatic resection could offer similar OS and RFS as those without diaphragmatic invasion.
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spelling pubmed-61336082018-09-19 Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion Zheng, Jinli Shen, Shu Jiang, Li Yan, Lunan Yang, Jiayin Li, Bo Wen, Tianfu Wang, WenTao Xu, Mingqing Medicine (Baltimore) Research Article The outcomes following anterior approach (AA) hepatectomy in huge hepatocellular carcinoma (HCC) patients with diaphragmatic invasion (DI) remain unclear. This study compared the outcomes of single huge right HCC patients with and without DI after AA hepatectomy. A total of 203 consecutive patients with single huge right lobe HCC who underwent AA major hepatectomy were included. They were divided into group PDI (n = 53) and group ADI (n = 150) according to the presence or the absence of DI. Their short- and long-term outcomes were compared, and a subgroup analysis was performed. There were no significant differences regarding postoperative complications and 90-day mortality between the 2 groups. The overall survival (OS) and recurrence-free survival (RFS) rates were similar between the 2 groups. The subgroup analysis also showed that patients with tumor resection en bloc with part of the diaphragm had similar OS and RFS rates as those who underwent diaphragmatic resection after hepatectomy. Tumor diameter ≥ 15 cm, serum AFP level ≥ 400 ng/mL, and tumor grade of G4 and microvascular invasion are independent predictors of poor prognosis. For the single huge right lobe HCC patients with DI, AA major hepatectomy combined with diaphragmatic resection could offer similar OS and RFS as those without diaphragmatic invasion. Wolters Kluwer Health 2018-09-07 /pmc/articles/PMC6133608/ /pubmed/30200125 http://dx.doi.org/10.1097/MD.0000000000012194 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Zheng, Jinli
Shen, Shu
Jiang, Li
Yan, Lunan
Yang, Jiayin
Li, Bo
Wen, Tianfu
Wang, WenTao
Xu, Mingqing
Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion
title Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion
title_full Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion
title_fullStr Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion
title_full_unstemmed Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion
title_short Outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe HCC with diaphragmatic invasion
title_sort outcomes of anterior approach major hepatectomy with diaphragmatic resection for single huge right lobe hcc with diaphragmatic invasion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133608/
https://www.ncbi.nlm.nih.gov/pubmed/30200125
http://dx.doi.org/10.1097/MD.0000000000012194
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