Exploration of serum sensitive biomarkers of fatty liver in dairy cows

Serum proteins are sensitive with diseases in dairy cows, and some of them could be used as biomarkers for fatty liver. This study aimed to explore serum biomarkers for fatty liver in dairy cows. A total of 28 early lactating dairy cows were chosen from a commercial dairy herds, liver samples were c...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Yizhao, Chen, Lianmin, Yang, Wenzhu, Wang, Zhonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133919/
https://www.ncbi.nlm.nih.gov/pubmed/30206404
http://dx.doi.org/10.1038/s41598-018-31845-0
_version_ 1783354571000643584
author Shen, Yizhao
Chen, Lianmin
Yang, Wenzhu
Wang, Zhonghua
author_facet Shen, Yizhao
Chen, Lianmin
Yang, Wenzhu
Wang, Zhonghua
author_sort Shen, Yizhao
collection PubMed
description Serum proteins are sensitive with diseases in dairy cows, and some of them could be used as biomarkers for fatty liver. This study aimed to explore serum biomarkers for fatty liver in dairy cows. A total of 28 early lactating dairy cows were chosen from a commercial dairy herds, liver samples were collected for determining concentration of triacylglycerol (TAG), and serum samples were collected for measuring fibroblast growth factor-21 (FGF-21), adiponectin, Lipoprotein-associated phospholipase A2 (LP-PLA2), and hemoglobin (Hb). Dairy cows were divided into fatty liver (liver TAG > 5%, wet weight) and control group (liver TAG < 5%, wet weight). Concentration of FGF-21 was greater in fatty liver cows, while the concentration of LP-PLA2 and Hb was less. The concentration of FGF-21 and total Hb had strong correlation with the liver TAG as well as good prediction power (kappa value = 0.79 and 0.58, respectively). These results suggested that the serum concentration of FGF-21 and total Hb could be potentially used as fatty liver biomarkers in lactating dairy cows.
format Online
Article
Text
id pubmed-6133919
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61339192018-09-15 Exploration of serum sensitive biomarkers of fatty liver in dairy cows Shen, Yizhao Chen, Lianmin Yang, Wenzhu Wang, Zhonghua Sci Rep Article Serum proteins are sensitive with diseases in dairy cows, and some of them could be used as biomarkers for fatty liver. This study aimed to explore serum biomarkers for fatty liver in dairy cows. A total of 28 early lactating dairy cows were chosen from a commercial dairy herds, liver samples were collected for determining concentration of triacylglycerol (TAG), and serum samples were collected for measuring fibroblast growth factor-21 (FGF-21), adiponectin, Lipoprotein-associated phospholipase A2 (LP-PLA2), and hemoglobin (Hb). Dairy cows were divided into fatty liver (liver TAG > 5%, wet weight) and control group (liver TAG < 5%, wet weight). Concentration of FGF-21 was greater in fatty liver cows, while the concentration of LP-PLA2 and Hb was less. The concentration of FGF-21 and total Hb had strong correlation with the liver TAG as well as good prediction power (kappa value = 0.79 and 0.58, respectively). These results suggested that the serum concentration of FGF-21 and total Hb could be potentially used as fatty liver biomarkers in lactating dairy cows. Nature Publishing Group UK 2018-09-11 /pmc/articles/PMC6133919/ /pubmed/30206404 http://dx.doi.org/10.1038/s41598-018-31845-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shen, Yizhao
Chen, Lianmin
Yang, Wenzhu
Wang, Zhonghua
Exploration of serum sensitive biomarkers of fatty liver in dairy cows
title Exploration of serum sensitive biomarkers of fatty liver in dairy cows
title_full Exploration of serum sensitive biomarkers of fatty liver in dairy cows
title_fullStr Exploration of serum sensitive biomarkers of fatty liver in dairy cows
title_full_unstemmed Exploration of serum sensitive biomarkers of fatty liver in dairy cows
title_short Exploration of serum sensitive biomarkers of fatty liver in dairy cows
title_sort exploration of serum sensitive biomarkers of fatty liver in dairy cows
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133919/
https://www.ncbi.nlm.nih.gov/pubmed/30206404
http://dx.doi.org/10.1038/s41598-018-31845-0
work_keys_str_mv AT shenyizhao explorationofserumsensitivebiomarkersoffattyliverindairycows
AT chenlianmin explorationofserumsensitivebiomarkersoffattyliverindairycows
AT yangwenzhu explorationofserumsensitivebiomarkersoffattyliverindairycows
AT wangzhonghua explorationofserumsensitivebiomarkersoffattyliverindairycows

Ejemplares similares