CDK4 inhibition diminishes p53 activation by MDM2 antagonists

The genes encoding MDM2 and CDK4 are frequently co-amplified in sarcomas, and inhibitors to both targets are approved or clinically tested for therapy. However, we show that inhibitors of MDM2 and CDK4 antagonize each other in their cytotoxicity towards sarcoma cells. CDK4 inhibition attenuates the...

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Detalles Bibliográficos
Autores principales: Sriraman, Anusha, Dickmanns, Antje, Najafova, Zeynab, Johnsen, Steven A., Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133967/
https://www.ncbi.nlm.nih.gov/pubmed/30206211
http://dx.doi.org/10.1038/s41419-018-0968-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133967/
https://www.ncbi.nlm.nih.gov/pubmed/30206211
http://dx.doi.org/10.1038/s41419-018-0968-0

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