Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis

An emerging paradigm proposes a crucial role for lung resident mesenchymal stem cells (LR-MSCs) via a fibroblastic transdifferentiation event in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Aberrant activation of Wnt/β-catenin signaling occurs in virtually all fibrotic lung diseases and...

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Detalles Bibliográficos
Autores principales: Cao, Honghui, Wang, Cong, Chen, Xiang, Hou, Jiwei, Xiang, Zou, Shen, Yi, Han, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134002/
https://www.ncbi.nlm.nih.gov/pubmed/30206265
http://dx.doi.org/10.1038/s41598-018-28968-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134002/
https://www.ncbi.nlm.nih.gov/pubmed/30206265
http://dx.doi.org/10.1038/s41598-018-28968-9

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