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Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis

An emerging paradigm proposes a crucial role for lung resident mesenchymal stem cells (LR-MSCs) via a fibroblastic transdifferentiation event in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Aberrant activation of Wnt/β-catenin signaling occurs in virtually all fibrotic lung diseases and...

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Detalles Bibliográficos
Autores principales:	Cao, Honghui, Wang, Cong, Chen, Xiang, Hou, Jiwei, Xiang, Zou, Shen, Yi, Han, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134002/ https://www.ncbi.nlm.nih.gov/pubmed/30206265 http://dx.doi.org/10.1038/s41598-018-28968-9

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