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The Transcriptional Regulation of Germinal Center Formation

Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector fu...

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Detalles Bibliográficos
Autores principales: Song, Shuang, Matthias, Patrick D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134015/
https://www.ncbi.nlm.nih.gov/pubmed/30233601
http://dx.doi.org/10.3389/fimmu.2018.02026
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author Song, Shuang
Matthias, Patrick D.
author_facet Song, Shuang
Matthias, Patrick D.
author_sort Song, Shuang
collection PubMed
description Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector function and higher affinity for the selected antigen. Remarkably, many of the B cell tumors have their origin in the GCs; thus, understanding how the formation of these structures is regulated or deregulated is of high medical importance. This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles in the process.
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spelling pubmed-61340152018-09-19 The Transcriptional Regulation of Germinal Center Formation Song, Shuang Matthias, Patrick D. Front Immunol Immunology Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector function and higher affinity for the selected antigen. Remarkably, many of the B cell tumors have their origin in the GCs; thus, understanding how the formation of these structures is regulated or deregulated is of high medical importance. This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles in the process. Frontiers Media S.A. 2018-09-05 /pmc/articles/PMC6134015/ /pubmed/30233601 http://dx.doi.org/10.3389/fimmu.2018.02026 Text en Copyright © 2018 Song and Matthias. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Song, Shuang
Matthias, Patrick D.
The Transcriptional Regulation of Germinal Center Formation
title The Transcriptional Regulation of Germinal Center Formation
title_full The Transcriptional Regulation of Germinal Center Formation
title_fullStr The Transcriptional Regulation of Germinal Center Formation
title_full_unstemmed The Transcriptional Regulation of Germinal Center Formation
title_short The Transcriptional Regulation of Germinal Center Formation
title_sort transcriptional regulation of germinal center formation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134015/
https://www.ncbi.nlm.nih.gov/pubmed/30233601
http://dx.doi.org/10.3389/fimmu.2018.02026
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