Cargando…

An Ad/MVA vectored Theileria parva antigen induces schizont-specific CD8(+) central memory T cells and confers partial protection against a lethal challenge

The parasite Theileria parva is the causative agent of East Coast fever (ECF), one of the most serious cattle diseases in sub-Saharan Africa, and directly impacts smallholder farmers’ livelihoods. There is an efficient live-parasite vaccine, but issues with transmission of vaccine strains, need of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Svitek, Nicholas, Saya, Rosemary, Awino, Elias, Munyao, Stephen, Muriuki, Robert, Njoroge, Thomas, Pellé, Roger, Ndiwa, Nicholas, Poole, Jane, Gilbert, Sarah, Nene, Vishvanath, Steinaa, Lucilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134044/ https://www.ncbi.nlm.nih.gov/pubmed/30245859 http://dx.doi.org/10.1038/s41541-018-0073-5

Ejemplares similares

Systematic Determination of TCR–Antigen and Peptide–MHC Binding Kinetics among Field Variants of a Theileria parva Polymorphic CTL Epitope
por: Svitek, Nicholas, et al.
Publicado: (2022)

Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity
por: Steinaa, Lucilla, et al.
Publicado: (2018)

Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals
por: Steinaa, Lucilla, et al.
Publicado: (2018)

Synergistic Effect of Two Nanotechnologies Enhances the Protective Capacity of the Theileria parva Sporozoite p67C Antigen in Cattle
por: Lacasta, Anna, et al.
Publicado: (2021)

Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever
por: Lacasta, Anna, et al.
Publicado: (2018)

Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro
por: Nyagwange, James, et al.
Publicado: (2018)

Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle
por: Svitek, Nicholas, et al.
Publicado: (2014)

Characterization of the Theileria parva sporozoite proteome
por: Nyagwange, James, et al.
Publicado: (2018)

Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
por: Bishop, Richard, et al.
Publicado: (2005)

Approaches to vaccination against Theileria parva and Theileria annulata
por: Nene, V., et al.
Publicado: (2016)

Characterisation of gp34, a GPI-anchored protein expressed by schizonts of Theileria parva and T. annulata
por: Xue, Gondga, et al.
Publicado: (2010)

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever
por: Nyagwange, James, et al.
Publicado: (2019)

Proteomic analysis of the Theileria annulata schizont
por: Witschi, M., et al.
Publicado: (2013)

Expression Analysis of the Theileria parva Subtelomere-Encoded Variable Secreted Protein Gene Family
por: Schmuckli-Maurer, Jacqueline, et al.
Publicado: (2009)

Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva
por: Tretina, Kyle, et al.
Publicado: (2016)

Re-annotation of the Theileria parva genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved pathway in many organisms
por: Tretina, Kyle, et al.
Publicado: (2020)

Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
por: Latre de Late, Perle, et al.
Publicado: (2021)

Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva
por: Sitt, Tatjana, et al.
Publicado: (2015)

Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional intra-specific genetic diversity
por: Palmateer, Nicholas C., et al.
Publicado: (2020)

In silico identification of Theileria parva surface proteins
por: Gurav, Nitisha, et al.
Publicado: (2022)

Recruitment of Host Nuclear Pore Components to the Vicinity of Theileria Schizonts
por: Huber, Sandra, et al.
Publicado: (2020)

Cell Cycle-Dependent Phosphorylation of Theileria annulata Schizont Surface Proteins
por: Wiens, Olga, et al.
Publicado: (2014)

South African Buffalo-Derived Theileria parva Is Distinct From Other Buffalo and Cattle-Derived T. parva
por: Maboko, Boitumelo B., et al.
Publicado: (2021)

Live immunisation against Theileria parva: containing or spreading the disease?
por: McKeever, Declan J.
Publicado: (2007)

Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro
por: Steketee, Pieter C., et al.
Publicado: (2023)

Two Theileria parva CD8 T Cell Antigen Genes Are More Variable in Buffalo than Cattle Parasites, but Differ in Pattern of Sequence Diversity
por: Pelle, Roger, et al.
Publicado: (2011)

TparvaDB: a database to support Theileria parva vaccine development
por: Visendi, Paul, et al.
Publicado: (2011)

Construction of a genetic map for Theileria parva: Identification of hotspots of recombination
por: Katzer, Frank, et al.
Publicado: (2011)

Genotypic diversity, a survival strategy for the apicomplexan parasite Theileria parva
por: Katzer, F., et al.
Publicado: (2010)

The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence
por: Norling, Martin, et al.
Publicado: (2015)

First detection of Theileria parva in cattle from Cameroon in the absence of the main tick vector Rhipicephalus appendiculatus
por: Silatsa, Barberine A., et al.
Publicado: (2020)

Prevalence of tick-transmitted pathogens in cattle reveals that Theileria parva, Babesia bigemina and Anaplasma marginale are endemic in Burundi
por: Nyabongo, Lionel, et al.
Publicado: (2021)

Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines
por: Sitt, Tatjana, et al.
Publicado: (2018)

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing
por: Henson, Sonal, et al.
Publicado: (2012)

Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva
por: Hemmink, Johanneke D., et al.
Publicado: (2016)

Recruitment of EB1, a Master Regulator of Microtubule Dynamics, to the Surface of the Theileria annulata Schizont
por: Woods, Kerry L., et al.
Publicado: (2013)

Changes in the Molecular and Functional Phenotype of Bovine Monocytes during Theileria parva Infection
por: Bastos, Reginaldo G., et al.
Publicado: (2019)

Comparative Transcriptomics of the Bovine Apicomplexan Parasite Theileria parva Developmental Stages Reveals Massive Gene Expression Variation and Potential Vaccine Antigens
por: Atchou, Kodzo, et al.
Publicado: (2020)

Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion
por: Tajeri, Shahin, et al.
Publicado: (2022)

Corrigendum to “Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva” [Int. J. Parasitol. Parasites Wildl. 4(2) (2015) 244–251]
por: Sitt, Tatjana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_s784gjna5r1kh57p6pphqs7tf9