Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels

Phagocytes destroy ingested microbes by producing hypochlorous acid (HOCl) from chloride ions (Cl(−)) and hydrogen peroxide within phagolysosomes, using the enzyme myeloperoxidase. HOCl, the active ingredient in bleach, has antibacterial/antiviral properties. As myeloperoxidase is needed for HOCl pr...

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Detalles Bibliográficos
Autores principales: Ramalingam, Sandeep, Cai, Baiyi, Wong, Junsheng, Twomey, Matthew, Chen, Rui, Fu, Rebecca M., Boote, Toby, McCaughan, Hugh, Griffiths, Samantha J., Haas, Jürgen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134045/
https://www.ncbi.nlm.nih.gov/pubmed/30206371
http://dx.doi.org/10.1038/s41598-018-31936-y

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