Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse

Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery...

Descripción completa

Detalles Bibliográficos
Autores principales: Castillo, Armando E., Rossoni, Sergio, Niven, Jeremy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134063/
https://www.ncbi.nlm.nih.gov/pubmed/30206296
http://dx.doi.org/10.1038/s41598-018-31996-0
_version_ 1783354604754305024
author Castillo, Armando E.
Rossoni, Sergio
Niven, Jeremy E.
author_facet Castillo, Armando E.
Rossoni, Sergio
Niven, Jeremy E.
author_sort Castillo, Armando E.
collection PubMed
description Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery at an excitatory synapse between the fast extensor tibiae (FETi) and flexor tibiae (flexor) motor neurons in the desert locust (Schistocerca gregaria) by making paired intracellular recordings in vivo. Over behaviorally relevant pre-synaptic spike frequencies, we found that this synapse undergoes matched frequency-dependent STD and recovery; higher frequency spikes that evoke stronger, faster STD also produce stronger, faster recovery. The precise matching of depression and recovery time constants at this synapse ensures that flexor excitatory post-synaptic potential (EPSP) amplitude encodes the presynaptic FETi interspike interval (ISI). Computational modelling shows that this precise matching enables the FETi-flexor synapse to linearly encode the ISI in the EPSP amplitude, a coding strategy that may be widespread in neural circuits.
format Online
Article
Text
id pubmed-6134063
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61340632018-09-15 Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse Castillo, Armando E. Rossoni, Sergio Niven, Jeremy E. Sci Rep Article Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery at an excitatory synapse between the fast extensor tibiae (FETi) and flexor tibiae (flexor) motor neurons in the desert locust (Schistocerca gregaria) by making paired intracellular recordings in vivo. Over behaviorally relevant pre-synaptic spike frequencies, we found that this synapse undergoes matched frequency-dependent STD and recovery; higher frequency spikes that evoke stronger, faster STD also produce stronger, faster recovery. The precise matching of depression and recovery time constants at this synapse ensures that flexor excitatory post-synaptic potential (EPSP) amplitude encodes the presynaptic FETi interspike interval (ISI). Computational modelling shows that this precise matching enables the FETi-flexor synapse to linearly encode the ISI in the EPSP amplitude, a coding strategy that may be widespread in neural circuits. Nature Publishing Group UK 2018-09-11 /pmc/articles/PMC6134063/ /pubmed/30206296 http://dx.doi.org/10.1038/s41598-018-31996-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Castillo, Armando E.
Rossoni, Sergio
Niven, Jeremy E.
Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
title Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
title_full Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
title_fullStr Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
title_full_unstemmed Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
title_short Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
title_sort matched short-term depression and recovery encodes interspike interval at a central synapse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134063/
https://www.ncbi.nlm.nih.gov/pubmed/30206296
http://dx.doi.org/10.1038/s41598-018-31996-0
work_keys_str_mv AT castilloarmandoe matchedshorttermdepressionandrecoveryencodesinterspikeintervalatacentralsynapse
AT rossonisergio matchedshorttermdepressionandrecoveryencodesinterspikeintervalatacentralsynapse
AT nivenjeremye matchedshorttermdepressionandrecoveryencodesinterspikeintervalatacentralsynapse