Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse
Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134063/ https://www.ncbi.nlm.nih.gov/pubmed/30206296 http://dx.doi.org/10.1038/s41598-018-31996-0 |
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author | Castillo, Armando E. Rossoni, Sergio Niven, Jeremy E. |
author_facet | Castillo, Armando E. Rossoni, Sergio Niven, Jeremy E. |
author_sort | Castillo, Armando E. |
collection | PubMed |
description | Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery at an excitatory synapse between the fast extensor tibiae (FETi) and flexor tibiae (flexor) motor neurons in the desert locust (Schistocerca gregaria) by making paired intracellular recordings in vivo. Over behaviorally relevant pre-synaptic spike frequencies, we found that this synapse undergoes matched frequency-dependent STD and recovery; higher frequency spikes that evoke stronger, faster STD also produce stronger, faster recovery. The precise matching of depression and recovery time constants at this synapse ensures that flexor excitatory post-synaptic potential (EPSP) amplitude encodes the presynaptic FETi interspike interval (ISI). Computational modelling shows that this precise matching enables the FETi-flexor synapse to linearly encode the ISI in the EPSP amplitude, a coding strategy that may be widespread in neural circuits. |
format | Online Article Text |
id | pubmed-6134063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61340632018-09-15 Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse Castillo, Armando E. Rossoni, Sergio Niven, Jeremy E. Sci Rep Article Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery at an excitatory synapse between the fast extensor tibiae (FETi) and flexor tibiae (flexor) motor neurons in the desert locust (Schistocerca gregaria) by making paired intracellular recordings in vivo. Over behaviorally relevant pre-synaptic spike frequencies, we found that this synapse undergoes matched frequency-dependent STD and recovery; higher frequency spikes that evoke stronger, faster STD also produce stronger, faster recovery. The precise matching of depression and recovery time constants at this synapse ensures that flexor excitatory post-synaptic potential (EPSP) amplitude encodes the presynaptic FETi interspike interval (ISI). Computational modelling shows that this precise matching enables the FETi-flexor synapse to linearly encode the ISI in the EPSP amplitude, a coding strategy that may be widespread in neural circuits. Nature Publishing Group UK 2018-09-11 /pmc/articles/PMC6134063/ /pubmed/30206296 http://dx.doi.org/10.1038/s41598-018-31996-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Castillo, Armando E. Rossoni, Sergio Niven, Jeremy E. Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse |
title | Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse |
title_full | Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse |
title_fullStr | Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse |
title_full_unstemmed | Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse |
title_short | Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse |
title_sort | matched short-term depression and recovery encodes interspike interval at a central synapse |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134063/ https://www.ncbi.nlm.nih.gov/pubmed/30206296 http://dx.doi.org/10.1038/s41598-018-31996-0 |
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