Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in CYP11A1 Gene

Context: The cholesterol side chain cleavage enzyme (CYP11A1) catalyzes the conversion of cholesterol to pregnenolone, the first rate-limiting step of steroidogenesis. CYP11A1 mutations are associated with primary adrenal insufficiency (PAI) as well as disorders of sex development (DSD) in 46,XY pat...

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Detalles Bibliográficos
Autores principales: Goursaud, Claire, Mallet, Delphine, Janin, Alexandre, Menassa, Rita, Tardy-Guidollet, Véronique, Russo, Gianni, Lienhardt-Roussie, Anne, Lecointre, Claudine, Plotton, Ingrid, Morel, Yves, Roucher-Boulez, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134065/
https://www.ncbi.nlm.nih.gov/pubmed/30233493
http://dx.doi.org/10.3389/fendo.2018.00491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134065/
https://www.ncbi.nlm.nih.gov/pubmed/30233493
http://dx.doi.org/10.3389/fendo.2018.00491

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