Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC expansion and behaviour. In this study, we determ...

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Detalles Bibliográficos
Autores principales: Toofan, Parto, Busch, Caroline, Morrison, Heather, O’Brien, Stephen, Jørgensen, Heather, Copland, Mhairi, Wheadon, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134087/
https://www.ncbi.nlm.nih.gov/pubmed/30206237
http://dx.doi.org/10.1038/s41419-018-0905-2

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