RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity

Human RecQL4 helicase plays critical roles in the maintenance of genomic stability. Mutations in RecQL4 helicase results in three clinically related autosomal recessive disorders: Rothmund–Thomson syndrome (RTS), RAPADILINO, and Baller–Gerold syndrome. In addition to several premature aging features...

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Detalles Bibliográficos
Autores principales: Fang, Hongbo, Niu, Kaifeng, Mo, Dongliang, Zhu, Yuqi, Tan, Qunsong, Wei, Di, Li, Yueyang, Chen, Zixiang, Yang, Shuchen, Balajee, Adayabalam S., Zhao, Yongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134139/
https://www.ncbi.nlm.nih.gov/pubmed/30206236
http://dx.doi.org/10.1038/s41389-018-0080-4

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