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Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors

Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We have used pharmacological and genetic approaches to identify the opioid receptors...

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Detalles Bibliográficos
Autores principales:	Pereira, Vanessa, Millet, Queensta, Aramburu, Jose, Lopez-Rodriguez, Cristina, Gaveriaux-Ruff, Claire, Wood, John N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134336/ https://www.ncbi.nlm.nih.gov/pubmed/30271888 http://dx.doi.org/10.12688/wellcomeopenres.14687.1

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