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Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134424/ https://www.ncbi.nlm.nih.gov/pubmed/30234067 http://dx.doi.org/10.22088/IJMCM.BUMS.7.1.1 |
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author | Yari, Mohsen Bitarafan, Sara Broumand, Mohammad Ali Fazeli, Zahra Rahimi, Mahnoosh Ghaderian, Sayyed Mohammad Hossein Mirfakhraie, Reza Omrani, Mir Davood |
author_facet | Yari, Mohsen Bitarafan, Sara Broumand, Mohammad Ali Fazeli, Zahra Rahimi, Mahnoosh Ghaderian, Sayyed Mohammad Hossein Mirfakhraie, Reza Omrani, Mir Davood |
author_sort | Yari, Mohsen |
collection | PubMed |
description | Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was determined by Real-Time PCR assay. The obtained data indicated that the EU741058 transcript expression level significantly decreased in CAD patients in comparison with the healthy individuals (P= 0.001). Furthermore, there was no significant association between the NR_003529 transcript expression, and CAD risk in Iranian patients (P=0.751). Our results suggest that the expression level of the EU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future. |
format | Online Article Text |
id | pubmed-6134424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-61344242018-09-19 Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease Yari, Mohsen Bitarafan, Sara Broumand, Mohammad Ali Fazeli, Zahra Rahimi, Mahnoosh Ghaderian, Sayyed Mohammad Hossein Mirfakhraie, Reza Omrani, Mir Davood Int J Mol Cell Med Original Article Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was determined by Real-Time PCR assay. The obtained data indicated that the EU741058 transcript expression level significantly decreased in CAD patients in comparison with the healthy individuals (P= 0.001). Furthermore, there was no significant association between the NR_003529 transcript expression, and CAD risk in Iranian patients (P=0.751). Our results suggest that the expression level of the EU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future. Babol University of Medical Sciences 2018 2018-02-10 /pmc/articles/PMC6134424/ /pubmed/30234067 http://dx.doi.org/10.22088/IJMCM.BUMS.7.1.1 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yari, Mohsen Bitarafan, Sara Broumand, Mohammad Ali Fazeli, Zahra Rahimi, Mahnoosh Ghaderian, Sayyed Mohammad Hossein Mirfakhraie, Reza Omrani, Mir Davood Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease |
title | Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease |
title_full | Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease |
title_fullStr | Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease |
title_full_unstemmed | Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease |
title_short | Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease |
title_sort | association between long noncoding rna anril expression variants and susceptibility to coronary artery disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134424/ https://www.ncbi.nlm.nih.gov/pubmed/30234067 http://dx.doi.org/10.22088/IJMCM.BUMS.7.1.1 |
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