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Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease

Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensi...

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Autores principales: Yari, Mohsen, Bitarafan, Sara, Broumand, Mohammad Ali, Fazeli, Zahra, Rahimi, Mahnoosh, Ghaderian, Sayyed Mohammad Hossein, Mirfakhraie, Reza, Omrani, Mir Davood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134424/
https://www.ncbi.nlm.nih.gov/pubmed/30234067
http://dx.doi.org/10.22088/IJMCM.BUMS.7.1.1
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author Yari, Mohsen
Bitarafan, Sara
Broumand, Mohammad Ali
Fazeli, Zahra
Rahimi, Mahnoosh
Ghaderian, Sayyed Mohammad Hossein
Mirfakhraie, Reza
Omrani, Mir Davood
author_facet Yari, Mohsen
Bitarafan, Sara
Broumand, Mohammad Ali
Fazeli, Zahra
Rahimi, Mahnoosh
Ghaderian, Sayyed Mohammad Hossein
Mirfakhraie, Reza
Omrani, Mir Davood
author_sort Yari, Mohsen
collection PubMed
description Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was determined by Real-Time PCR assay. The obtained data indicated that the EU741058 transcript expression level significantly decreased in CAD patients in comparison with the healthy individuals (P= 0.001). Furthermore, there was no significant association between the NR_003529 transcript expression, and CAD risk in Iranian patients (P=0.751). Our results suggest that the expression level of the EU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future.
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spelling pubmed-61344242018-09-19 Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease Yari, Mohsen Bitarafan, Sara Broumand, Mohammad Ali Fazeli, Zahra Rahimi, Mahnoosh Ghaderian, Sayyed Mohammad Hossein Mirfakhraie, Reza Omrani, Mir Davood Int J Mol Cell Med Original Article Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL. Peripheral blood was taken from fifty patients affected by CAD and relative expression of ANRIL was determined by Real-Time PCR assay. The obtained data indicated that the EU741058 transcript expression level significantly decreased in CAD patients in comparison with the healthy individuals (P= 0.001). Furthermore, there was no significant association between the NR_003529 transcript expression, and CAD risk in Iranian patients (P=0.751). Our results suggest that the expression level of the EU741058 transcript of ANRIL may be implicated in CAD development, creating a predictive biomarker for CAD patients in future. Babol University of Medical Sciences 2018 2018-02-10 /pmc/articles/PMC6134424/ /pubmed/30234067 http://dx.doi.org/10.22088/IJMCM.BUMS.7.1.1 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yari, Mohsen
Bitarafan, Sara
Broumand, Mohammad Ali
Fazeli, Zahra
Rahimi, Mahnoosh
Ghaderian, Sayyed Mohammad Hossein
Mirfakhraie, Reza
Omrani, Mir Davood
Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
title Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
title_full Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
title_fullStr Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
title_full_unstemmed Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
title_short Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease
title_sort association between long noncoding rna anril expression variants and susceptibility to coronary artery disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134424/
https://www.ncbi.nlm.nih.gov/pubmed/30234067
http://dx.doi.org/10.22088/IJMCM.BUMS.7.1.1
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