The complement system in glioblastoma multiforme

The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recen...

Descripción completa

Detalles Bibliográficos
Autores principales: Bouwens van der Vlis, T. A. M., Kros, J. M., Mustafa, D. A. M., van Wijck, R. T. A., Ackermans, L., van Hagen, P. M., van der Spek, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134703/
https://www.ncbi.nlm.nih.gov/pubmed/30208949
http://dx.doi.org/10.1186/s40478-018-0591-4
Descripción
Sumario:The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.

Ejemplares similares