The complement system in glioblastoma multiforme

The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recen...

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Autores principales: Bouwens van der Vlis, T. A. M., Kros, J. M., Mustafa, D. A. M., van Wijck, R. T. A., Ackermans, L., van Hagen, P. M., van der Spek, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134703/
https://www.ncbi.nlm.nih.gov/pubmed/30208949
http://dx.doi.org/10.1186/s40478-018-0591-4
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author Bouwens van der Vlis, T. A. M.
Kros, J. M.
Mustafa, D. A. M.
van Wijck, R. T. A.
Ackermans, L.
van Hagen, P. M.
van der Spek, P. J.
author_facet Bouwens van der Vlis, T. A. M.
Kros, J. M.
Mustafa, D. A. M.
van Wijck, R. T. A.
Ackermans, L.
van Hagen, P. M.
van der Spek, P. J.
author_sort Bouwens van der Vlis, T. A. M.
collection PubMed
description The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.
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spelling pubmed-61347032018-09-13 The complement system in glioblastoma multiforme Bouwens van der Vlis, T. A. M. Kros, J. M. Mustafa, D. A. M. van Wijck, R. T. A. Ackermans, L. van Hagen, P. M. van der Spek, P. J. Acta Neuropathol Commun Review The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions. BioMed Central 2018-09-12 /pmc/articles/PMC6134703/ /pubmed/30208949 http://dx.doi.org/10.1186/s40478-018-0591-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Bouwens van der Vlis, T. A. M.
Kros, J. M.
Mustafa, D. A. M.
van Wijck, R. T. A.
Ackermans, L.
van Hagen, P. M.
van der Spek, P. J.
The complement system in glioblastoma multiforme
title The complement system in glioblastoma multiforme
title_full The complement system in glioblastoma multiforme
title_fullStr The complement system in glioblastoma multiforme
title_full_unstemmed The complement system in glioblastoma multiforme
title_short The complement system in glioblastoma multiforme
title_sort complement system in glioblastoma multiforme
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134703/
https://www.ncbi.nlm.nih.gov/pubmed/30208949
http://dx.doi.org/10.1186/s40478-018-0591-4
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