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Achalasia in a Patient Undergoing Hematologic Stem Cell Transplant After Exposure to Tacrolimus

Calcineurin inhibitors (CNIs) are effective agents used for prevention of graft-vs-host disease after allogeneic hematopoietic stem cell transplant or for organ rejection in solid-organ transplant. However, CNIs have a wide range of adverse effects that may necessitate changing to another CNI or imm...

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Detalles Bibliográficos
Autores principales: Goklemez, Sencer, Curtis, Lauren M., Hawwa, Alao, Ling, Alexander, Avila, Daniele, Heller, Theo, Pavletic, Steven Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134909/
https://www.ncbi.nlm.nih.gov/pubmed/30225417
http://dx.doi.org/10.1016/j.mayocpiqo.2017.06.004
Descripción
Sumario:Calcineurin inhibitors (CNIs) are effective agents used for prevention of graft-vs-host disease after allogeneic hematopoietic stem cell transplant or for organ rejection in solid-organ transplant. However, CNIs have a wide range of adverse effects that may necessitate changing to another CNI or immunosuppressive agent. We report a case of acute myeloid leukemia in which achalasia developed after exposure to tacrolimus, as revealed by esophagram results. The patient's symptoms and signs were ameliorated after a change to cyclosporine. This case is the first in the literature to reveal achalasia associated with tacrolimus. Achalasia should be part of a differential diagnosis of upper gastrointestinal symptoms in patients undergoing transplant, and changing to another CNI may be a useful therapeutic intervention.