Complete androgen insensitivity syndrome and anti-Müllerian hormone levels before and after laparoscopic gonadectomy

We report cases of two sisters with complete androgen insensitivity syndrome (CAIS). A complete female appearance, blind-ending vagina, and testes in the pelvis are characteristics of CAIS. Prophylactic laparoscopic gonadectomy was performed in both cases. Anti-Müllerian hormone (AMH) level is known...

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Detalles Bibliográficos
Autores principales: Kusumi, Maki, Mitsunami, Makiko, Onoue, Hiroki, Noma, Momo, Matsumura, Fumiko, Tabata, Chisa, Tanaka, Seiji, Watanabe, Noriko, Kurosawa, Takako, Fujiwara, Toshihiro, Tsutusmi, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135182/
https://www.ncbi.nlm.nih.gov/pubmed/30254896
http://dx.doi.org/10.1016/j.gmit.2016.11.001
Descripción
Sumario:We report cases of two sisters with complete androgen insensitivity syndrome (CAIS). A complete female appearance, blind-ending vagina, and testes in the pelvis are characteristics of CAIS. Prophylactic laparoscopic gonadectomy was performed in both cases. Anti-Müllerian hormone (AMH) level is known to be very high in patients with CAIS; AMH is secreted by Sertoli cells and testosterone suppresses the secretion. In our cases, serum AMH was very high before gonadectomy and dramatically decreased after gonadectomy. AMH could be the diagnostic feature for patients with CAIS.

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