Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice

BACKGROUND: A direct and independent role of inflammation in atherothrombosis was recently highlighted by the Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial, showing the benefit of inhibiting signaling molecules, eg, interleukins. Accordingly, we sought to devise a flexible pla...

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Detalles Bibliográficos
Autores principales: Pan, Hua, Palekar, Rohun U, Hou, Kirk K, Bacon, John, Yan, Huimin, Springer, Luke E, Akk, Antonina, Yang, Lihua, Miller, Mark J, Pham, Christine TN, Schlesinger, Paul H, Wickline, Samuel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135209/
https://www.ncbi.nlm.nih.gov/pubmed/30233180
http://dx.doi.org/10.2147/IJN.S168556

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