Cargando…

Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin

Hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) are first-line medication for lowering serum cholesterol levels in the prevention of cardiovascular disease. Angioedema is the swelling of mucosa and submucosal tissue. There are no published cases of drug-induced angioedema involving...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahbaz, Amir, Mahendhar, Rupak, Fransawy Alkomos, Mina, Zarghamravanbakhsh, Paria, Sachmechi, Issac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135297/
https://www.ncbi.nlm.nih.gov/pubmed/30210953
http://dx.doi.org/10.7759/cureus.2965
_version_ 1783354799950921728
author Shahbaz, Amir
Mahendhar, Rupak
Fransawy Alkomos, Mina
Zarghamravanbakhsh, Paria
Sachmechi, Issac
author_facet Shahbaz, Amir
Mahendhar, Rupak
Fransawy Alkomos, Mina
Zarghamravanbakhsh, Paria
Sachmechi, Issac
author_sort Shahbaz, Amir
collection PubMed
description Hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) are first-line medication for lowering serum cholesterol levels in the prevention of cardiovascular disease. Angioedema is the swelling of mucosa and submucosal tissue. There are no published cases of drug-induced angioedema involving rosuvastatin. We report a case of a 45-year-old female who presented with episodes of self-resolving edema of face, lips, and tongue after being on rosuvastatin. The patient denied any rash during these episodes and mentioned that self-medication with diphenhydramine did not relieve her symptoms. The patient was hemodynamically stable. The complement component 4 (C4), C1 esterase inhibitor, and complement component 1q (C1q) binding assay were within normal range. Therefore, the diagnosis of hereditary angioedema was effectively ruled out. The temporal relation between rosuvastatin and the development of angioedema and prompt resolution of symptoms after the drug discontinued suggest that rosuvastatin was the most probable culprit in the development of angioedema in our patient.
format Online
Article
Text
id pubmed-6135297
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-61352972018-09-12 Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin Shahbaz, Amir Mahendhar, Rupak Fransawy Alkomos, Mina Zarghamravanbakhsh, Paria Sachmechi, Issac Cureus Internal Medicine Hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) are first-line medication for lowering serum cholesterol levels in the prevention of cardiovascular disease. Angioedema is the swelling of mucosa and submucosal tissue. There are no published cases of drug-induced angioedema involving rosuvastatin. We report a case of a 45-year-old female who presented with episodes of self-resolving edema of face, lips, and tongue after being on rosuvastatin. The patient denied any rash during these episodes and mentioned that self-medication with diphenhydramine did not relieve her symptoms. The patient was hemodynamically stable. The complement component 4 (C4), C1 esterase inhibitor, and complement component 1q (C1q) binding assay were within normal range. Therefore, the diagnosis of hereditary angioedema was effectively ruled out. The temporal relation between rosuvastatin and the development of angioedema and prompt resolution of symptoms after the drug discontinued suggest that rosuvastatin was the most probable culprit in the development of angioedema in our patient. Cureus 2018-07-11 /pmc/articles/PMC6135297/ /pubmed/30210953 http://dx.doi.org/10.7759/cureus.2965 Text en Copyright © 2018, Shahbaz et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Shahbaz, Amir
Mahendhar, Rupak
Fransawy Alkomos, Mina
Zarghamravanbakhsh, Paria
Sachmechi, Issac
Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin
title Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin
title_full Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin
title_fullStr Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin
title_full_unstemmed Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin
title_short Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin
title_sort drug-induced angioedema: a rare side effect of rosuvastatin
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135297/
https://www.ncbi.nlm.nih.gov/pubmed/30210953
http://dx.doi.org/10.7759/cureus.2965
work_keys_str_mv AT shahbazamir druginducedangioedemaararesideeffectofrosuvastatin
AT mahendharrupak druginducedangioedemaararesideeffectofrosuvastatin
AT fransawyalkomosmina druginducedangioedemaararesideeffectofrosuvastatin
AT zarghamravanbakhshparia druginducedangioedemaararesideeffectofrosuvastatin
AT sachmechiissac druginducedangioedemaararesideeffectofrosuvastatin