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Dimerization misalignment in human glutamate-oxaloacetate transaminase variants is the primary factor for PLP release

The active form of vitamin B6, pyridoxal 5’-phosphate (PLP), plays an essential role in the catalytic mechanism of various proteins, including human glutamate-oxaloacetate transaminase (hGOT1), an important enzyme in amino acid metabolism. A recent molecular and genetic study showed that the E266K,...

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Detalles Bibliográficos
Autores principales:	Lee, Jesi, Gokey, Trevor, Ting, Dylan, He, Zheng-Hui, Guliaev, Anton B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135512/ https://www.ncbi.nlm.nih.gov/pubmed/30208107 http://dx.doi.org/10.1371/journal.pone.0203889

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