Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

High lethality rates associated with metastatic cancer highlight an urgent medical need for improved understanding of biologic mechanisms driving metastatic spread and identification of biomarkers predicting late-stage progression. Numerous neoplastic cell intrinsic and extrinsic mechanisms fuel tum...

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Detalles Bibliográficos
Autores principales: Gast, Charles E., Silk, Alain D., Zarour, Luai, Riegler, Lara, Burkhart, Joshua G., Gustafson, Kyle T., Parappilly, Michael S., Roh-Johnson, Minna, Goodman, James R., Olson, Brennan, Schmidt, Mark, Swain, John R., Davies, Paige S., Shasthri, Vidya, Iizuka, Shinji, Flynn, Patrick, Watson, Spencer, Korkola, James, Courtneidge, Sara A., Fischer, Jared M., Jaboin, Jerry, Billingsley, Kevin G., Lopez, Charles D., Burchard, Julja, Gray, Joe, Coussens, Lisa M., Sheppard, Brett C., Wong, Melissa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135550/
https://www.ncbi.nlm.nih.gov/pubmed/30214939
http://dx.doi.org/10.1126/sciadv.aat7828

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