Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

Poly(ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a chromatin architectural protein. How PARP1 rapidly finds DNA damage sites in the context of a nucleus filled with undamaged DNA, to which it also binds, is an unresolved question. Here, we show that PARP1 association...

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Detalles Bibliográficos
Autores principales: Rudolph, Johannes, Mahadevan, Jyothi, Dyer, Pamela, Luger, Karolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135609/
https://www.ncbi.nlm.nih.gov/pubmed/30088474
http://dx.doi.org/10.7554/eLife.37818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135609/
https://www.ncbi.nlm.nih.gov/pubmed/30088474
http://dx.doi.org/10.7554/eLife.37818

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