A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)

Anti-cancer drug discovery efforts to directly inhibit the signal transducer and activator of transcription 3 (STAT3) have been active for over a decade following the discovery that 70% of cancers exhibit elevated STAT3 activity. The majority of research has focused on attenuating STAT3 activity thr...

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Detalles Bibliográficos
Autores principales: Shih, Po-Chang, Yang, Yiwen, Parkinson, Gary N., Wilderspin, Andrew, Wells, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135694/
https://www.ncbi.nlm.nih.gov/pubmed/30220975
http://dx.doi.org/10.18632/oncotarget.26013

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