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Task-evoked pupil responses reflect internal belief states

Perceptual decisions about the state of the environment are often made in the face of uncertain evidence. Internal uncertainty signals are considered important regulators of learning and decision-making. A growing body of work has implicated the brain’s arousal systems in uncertainty signaling. Here...

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Autores principales: Colizoli, Olympia, de Gee, Jan Willem, Urai, Anne E., Donner, Tobias H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135755/
https://www.ncbi.nlm.nih.gov/pubmed/30209335
http://dx.doi.org/10.1038/s41598-018-31985-3
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author Colizoli, Olympia
de Gee, Jan Willem
Urai, Anne E.
Donner, Tobias H.
author_facet Colizoli, Olympia
de Gee, Jan Willem
Urai, Anne E.
Donner, Tobias H.
author_sort Colizoli, Olympia
collection PubMed
description Perceptual decisions about the state of the environment are often made in the face of uncertain evidence. Internal uncertainty signals are considered important regulators of learning and decision-making. A growing body of work has implicated the brain’s arousal systems in uncertainty signaling. Here, we found that two specific computational variables, postulated by recent theoretical work, evoke boosts of arousal at different times during a perceptual decision: decision confidence (the observer’s internally estimated probability that a choice was correct given the evidence) before feedback, and prediction errors (deviations from expected reward) after feedback. We monitored pupil diameter, a peripheral marker of central arousal state, while subjects performed a challenging perceptual choice task with a delayed monetary reward. We quantified evoked pupil responses during decision formation and after reward-linked feedback. During both intervals, decision difficulty and accuracy had interacting effects on pupil responses. Pupil responses negatively scaled with decision confidence prior to feedback and scaled with uncertainty-dependent prediction errors after feedback. This pattern of pupil responses during both intervals was in line with a model using the observer’s graded belief about choice accuracy to anticipate rewards and compute prediction errors. We conclude that pupil-linked arousal systems are modulated by internal belief states.
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spelling pubmed-61357552018-09-15 Task-evoked pupil responses reflect internal belief states Colizoli, Olympia de Gee, Jan Willem Urai, Anne E. Donner, Tobias H. Sci Rep Article Perceptual decisions about the state of the environment are often made in the face of uncertain evidence. Internal uncertainty signals are considered important regulators of learning and decision-making. A growing body of work has implicated the brain’s arousal systems in uncertainty signaling. Here, we found that two specific computational variables, postulated by recent theoretical work, evoke boosts of arousal at different times during a perceptual decision: decision confidence (the observer’s internally estimated probability that a choice was correct given the evidence) before feedback, and prediction errors (deviations from expected reward) after feedback. We monitored pupil diameter, a peripheral marker of central arousal state, while subjects performed a challenging perceptual choice task with a delayed monetary reward. We quantified evoked pupil responses during decision formation and after reward-linked feedback. During both intervals, decision difficulty and accuracy had interacting effects on pupil responses. Pupil responses negatively scaled with decision confidence prior to feedback and scaled with uncertainty-dependent prediction errors after feedback. This pattern of pupil responses during both intervals was in line with a model using the observer’s graded belief about choice accuracy to anticipate rewards and compute prediction errors. We conclude that pupil-linked arousal systems are modulated by internal belief states. Nature Publishing Group UK 2018-09-12 /pmc/articles/PMC6135755/ /pubmed/30209335 http://dx.doi.org/10.1038/s41598-018-31985-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Colizoli, Olympia
de Gee, Jan Willem
Urai, Anne E.
Donner, Tobias H.
Task-evoked pupil responses reflect internal belief states
title Task-evoked pupil responses reflect internal belief states
title_full Task-evoked pupil responses reflect internal belief states
title_fullStr Task-evoked pupil responses reflect internal belief states
title_full_unstemmed Task-evoked pupil responses reflect internal belief states
title_short Task-evoked pupil responses reflect internal belief states
title_sort task-evoked pupil responses reflect internal belief states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135755/
https://www.ncbi.nlm.nih.gov/pubmed/30209335
http://dx.doi.org/10.1038/s41598-018-31985-3
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