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Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells

Doxorubicin is one of the most effective chemotherapy drugs used against solid tumors in the treatment of several cancer types. Two different mechanisms, (i) intercalation of doxorubicin into DNA and inhibition of topoisomerase II leading to changes in chromatin structure, (ii) generation of free ra...

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Detalles Bibliográficos
Autores principales:	Taymaz-Nikerel, Hilal, Karabekmez, Muhammed Erkan, Eraslan, Serpil, Kırdar, Betül
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135803/ https://www.ncbi.nlm.nih.gov/pubmed/30209405 http://dx.doi.org/10.1038/s41598-018-31939-9

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