Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

Inhibitors of phosphodiesterase-4 (PDE4) have beneficial effects on memory in preclinical and clinical studies. Development of these drugs has stalled due to dose-limiting side effects of nausea and emesis. While use of subtype-selective inhibitors (i.e., for PDE4A, B, or D) could overcome this issu...

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Detalles Bibliográficos
Autores principales: Zhang, Chong, Xu, Ying, Chowdhary, Anirudh, Fox, David, Gurney, Mark E., Zhang, Han-Ting, Auerbach, Benjamin D., Salvi, Richard J., Yang, Mingxin, Li, Gaowen, O’Donnell, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135860/
https://www.ncbi.nlm.nih.gov/pubmed/30131563
http://dx.doi.org/10.1038/s41386-018-0178-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135860/
https://www.ncbi.nlm.nih.gov/pubmed/30131563
http://dx.doi.org/10.1038/s41386-018-0178-6

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