Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes. However, methods for SD reconstitution have been unavailable, thereby limiting studies in the field. In the present study, we establ...

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Detalles Bibliográficos
Autores principales: Tanigawa, Shunsuke, Islam, Mazharul, Sharmin, Sazia, Naganuma, Hidekazu, Yoshimura, Yasuhiro, Haque, Fahim, Era, Takumi, Nakazato, Hitoshi, Nakanishi, Koichi, Sakuma, Tetsushi, Yamamoto, Takashi, Kurihara, Hidetake, Taguchi, Atsuhiro, Nishinakamura, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135868/
https://www.ncbi.nlm.nih.gov/pubmed/30174315
http://dx.doi.org/10.1016/j.stemcr.2018.08.003

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