Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging

Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. Individuals with DS exhibit changes in neurochemistry and neuroanatomy that worsen with age, neurological delay in learning and memory, and predisposition to Alzheimer’s disease. The...

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Detalles Bibliográficos
Autores principales: Duval, Nathan, Vacano, Guido N., Patterson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135881/
https://www.ncbi.nlm.nih.gov/pubmed/30237765
http://dx.doi.org/10.3389/fnagi.2018.00263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135881/
https://www.ncbi.nlm.nih.gov/pubmed/30237765
http://dx.doi.org/10.3389/fnagi.2018.00263

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