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N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135926/ https://www.ncbi.nlm.nih.gov/pubmed/30428366 http://dx.doi.org/10.1016/j.isci.2018.03.006 |
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author | Chen, Xiang-Yu Li, Sun Vetica, Fabrizio Kumar, Mukesh Enders, Dieter |
author_facet | Chen, Xiang-Yu Li, Sun Vetica, Fabrizio Kumar, Mukesh Enders, Dieter |
author_sort | Chen, Xiang-Yu |
collection | PubMed |
description | Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significant progress since the different activation modes could be successfully combined in one process. The most attractive features of these domino sequences include the readily available catalysts and substrates, the simple operational procedures, and the rapid assembly of complex molecular scaffolds with excellent levels of stereocontrol under mild reaction conditions. This review covers the advances in NHC-catalyzed domino reactions by focusing on the reaction scope, limitations, and mechanism with a close attention to the features of the reaction substrates. |
format | Online Article Text |
id | pubmed-6135926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61359262018-09-17 N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes Chen, Xiang-Yu Li, Sun Vetica, Fabrizio Kumar, Mukesh Enders, Dieter iScience Review Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significant progress since the different activation modes could be successfully combined in one process. The most attractive features of these domino sequences include the readily available catalysts and substrates, the simple operational procedures, and the rapid assembly of complex molecular scaffolds with excellent levels of stereocontrol under mild reaction conditions. This review covers the advances in NHC-catalyzed domino reactions by focusing on the reaction scope, limitations, and mechanism with a close attention to the features of the reaction substrates. Elsevier 2018-04-05 /pmc/articles/PMC6135926/ /pubmed/30428366 http://dx.doi.org/10.1016/j.isci.2018.03.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Chen, Xiang-Yu Li, Sun Vetica, Fabrizio Kumar, Mukesh Enders, Dieter N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes |
title | N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes |
title_full | N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes |
title_fullStr | N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes |
title_full_unstemmed | N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes |
title_short | N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes |
title_sort | n-heterocyclic-carbene-catalyzed domino reactions via two or more activation modes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135926/ https://www.ncbi.nlm.nih.gov/pubmed/30428366 http://dx.doi.org/10.1016/j.isci.2018.03.006 |
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