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N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes

Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significa...

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Detalles Bibliográficos
Autores principales: Chen, Xiang-Yu, Li, Sun, Vetica, Fabrizio, Kumar, Mukesh, Enders, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135926/
https://www.ncbi.nlm.nih.gov/pubmed/30428366
http://dx.doi.org/10.1016/j.isci.2018.03.006
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author Chen, Xiang-Yu
Li, Sun
Vetica, Fabrizio
Kumar, Mukesh
Enders, Dieter
author_facet Chen, Xiang-Yu
Li, Sun
Vetica, Fabrizio
Kumar, Mukesh
Enders, Dieter
author_sort Chen, Xiang-Yu
collection PubMed
description Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significant progress since the different activation modes could be successfully combined in one process. The most attractive features of these domino sequences include the readily available catalysts and substrates, the simple operational procedures, and the rapid assembly of complex molecular scaffolds with excellent levels of stereocontrol under mild reaction conditions. This review covers the advances in NHC-catalyzed domino reactions by focusing on the reaction scope, limitations, and mechanism with a close attention to the features of the reaction substrates.
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spelling pubmed-61359262018-09-17 N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes Chen, Xiang-Yu Li, Sun Vetica, Fabrizio Kumar, Mukesh Enders, Dieter iScience Review Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significant progress since the different activation modes could be successfully combined in one process. The most attractive features of these domino sequences include the readily available catalysts and substrates, the simple operational procedures, and the rapid assembly of complex molecular scaffolds with excellent levels of stereocontrol under mild reaction conditions. This review covers the advances in NHC-catalyzed domino reactions by focusing on the reaction scope, limitations, and mechanism with a close attention to the features of the reaction substrates. Elsevier 2018-04-05 /pmc/articles/PMC6135926/ /pubmed/30428366 http://dx.doi.org/10.1016/j.isci.2018.03.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Chen, Xiang-Yu
Li, Sun
Vetica, Fabrizio
Kumar, Mukesh
Enders, Dieter
N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
title N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
title_full N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
title_fullStr N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
title_full_unstemmed N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
title_short N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
title_sort n-heterocyclic-carbene-catalyzed domino reactions via two or more activation modes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135926/
https://www.ncbi.nlm.nih.gov/pubmed/30428366
http://dx.doi.org/10.1016/j.isci.2018.03.006
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