Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin

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YAP and TAZ, the Hippo signal-regulated transcriptional co-activators, play crucial roles in morphogenesis and organogenesis. Here we report that the YAP/TAZ activities are stimulated upon complex formation with Parafibromin, which undergoes tyrosine phosphorylation and dephosphorylation by kinases...

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Detalles Bibliográficos
Autores principales: Tang, Chao, Takahashi-Kanemitsu, Atsushi, Kikuchi, Ippei, Ben, Chi, Hatakeyama, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135933/
https://www.ncbi.nlm.nih.gov/pubmed/30227954
http://dx.doi.org/10.1016/j.isci.2018.01.003

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