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Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity

The tissue inhibitor of metalloproteinases 2 (TIMP-2) is a specific endogenous inhibitor of matrix metalloproteinase 2 (MMP-2), which is a key enzyme that degrades the extracellular matrix and promotes tumor cell invasion. Although the TIMP-2:MMP-2 complex controls proteolysis, the signaling mechani...

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Detalles Bibliográficos
Autores principales:	Sánchez-Pozo, Javier, Baker-Williams, Alexander J., Woodford, Mark R., Bullard, Renee, Wei, Beiyang, Mollapour, Mehdi, Stetler-Stevenson, William G., Bratslavsky, Gennady, Bourboulia, Dimitra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135941/ https://www.ncbi.nlm.nih.gov/pubmed/30227959 http://dx.doi.org/10.1016/j.isci.2018.02.004

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