Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach

Hematopoietic stem cells (HSCs) develop in the embryonic aorta-gonad-mesonephros (AGM) region and subsequently relocate to fetal liver. Runx1 transcription factor is essential for HSC development, but is largely dispensable for adult HSCs. Here, we studied tamoxifen-inducible Runx1 inactivation in v...

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Detalles Bibliográficos
Autores principales: Senserrich, Jordi, Batsivari, Antoniana, Rybtsov, Stanislav, Gordon-Keylock, Sabrina, Souilhol, Celine, Buchholz, Frank, Hills, David, Zhao, Suling, Medvinsky, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135942/
https://www.ncbi.nlm.nih.gov/pubmed/30208304
http://dx.doi.org/10.1016/j.stemcr.2018.08.004

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